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Lipid management in the context of good glycaemic control using simvastatin (20 mg daily for primary prevention and 40 mg daily for secondary prevention) in all patients with the addition of fenofibrate or placebo.

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In adults with CVD risk greater than 1% per year, the number of CVD events prevented will be similar to or greater than the number of episodes of bleeding induced, although these complications do not have equal effects on long-term health ().

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