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The invention provides capsules, sprays, powders, lotions, tablets or pills comprising a preparation of the invention or formulation of the invention.

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For example, in one aspect the therapeutic combinations of the invention are packaged in dosages that match a chrono-dosing regimen comprising: (a) in the AM, 20 mg propranolol, 200 mg etodolac; in the afternoon, 10 mg propranolol, 200 mg etodolac; in the PM, 10 mg propranolol, 400 mg etodolac; (b) in the AM 40 mg propranolol, 200 mg etodolac; in the afternoon 20 mg propranolol, 200 mg etodolac; in the evening, 20 mg propranolol, 400 mg etodolac; (c) in the AM 80 mg propranolol, 200 mg etodolac; in the afternoon 40 mg propranolol, 200 mg etodolac, in the evening 40 mg, etodolac; or (d) a dose escalation comprising a regimen of (a) to (b) to (c); or any equivalents.

The future of traditional nonsteroidal antiinflammatory drugs and cyclooxygenase-2 inhibitors in the treatment of inflammation and pain.

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In alternative aspects, a therapy provided herein comprises or consists of at least one member selected from Group J, and at least one member selected from Group L, as shown in Table 1, where: Group J comprises α-difluoromethylornithine; and Group L comprises activators of heat shock response.

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Some clinical trials and meta-analysis showed that treatment with some COXIBs (in particular Vioxx, rofecoxib) led to increased incidence of adverse cardiovascular events compared to placebo.

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The blister pack or a plurality of blister packettes, a blister package, a lidded blister or a blister card or packet, a clamshell, a tray or a shrink wrap of aspect 91 or aspect 92, or the paper, plastic or cellophane package or a plurality of packettes of aspect 93 or aspect 94, wherein the drug combination is formulated, packaged or designed for drug regimen compliance of a cancer patient population having mild or severe mental retardation, slow cognition, dementia, senility, Alzheimer's disease, traumatic brain injury, chemical brain damage, mental diseases (e.

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In one embodiment, the invention provides pharmaceutical compositions or formulations comprising a therapeutic combination of drugs of the invention; and the therapeutic combination can further comprise or further consist of a pharmaceutically acceptable excipient.

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Supportive care, as provided herein for protection in this invention, includes G-CSF therapy, and erythropoietin therapy.

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The use of claim 113, wherein the stressed, challenged or non-compliant patient population comprises a cancer patient population; or a patient population having mild or severe mental retardation, slow cognition, dementia, senility, Alzheimer's disease, traumatic brain injury, chemical brain damage or a mental disease; or post-traumatic stress disorder, traumatic war neurosis, post-traumatic stress syndrome (PTSS) or a physical disability or blindness.

Briefing Documents Nonprescription Drug Advisory Committee Meeting Cold, Cough, Allergy, Bronchodilator, Antiasthmatic Drug Products for Over-the-Counter Human Use, October 18 and 19, 2007.

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The product of manufacture of claim 85, wherein the dosage schedule provides a relatively higher dose of one drug in the morning (the AM) than in the evening, and a relatively higher dose of another medication in the evening than in the morning.

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In one embodiment, high dosages of propranolol are given in the morning and lower dosages of propranolol are given at night; with low dosages of etodolac in the morning and higher levels of etodolac at night.

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The blister pack or a plurality of blister packettes, a blister package, a lidded blister or a blister card or packet, a clamshell, a tray or a shrink wrap of aspect 91 or aspect 92, or the paper, plastic or cellophane package or a plurality of packettes of aspect 93 or aspect 94, wherein the drug combination is formulated, packaged or designed for drug regimen compliance of a cancer patient population, a pediatric or geriatric population, or a mentally compromised patient population.

Any combination comprising or consisting of One Member of Group F and One Member of Group I (see Table 1).

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Systemic Inflammatory Response State (SIRS), wherein the therapeutic combination of any of claims 1 to 53, or the pharmaceutical composition or formulation of any of claims 54 to 56, is administered to an individual in need thereof, and the therapeutic combination or the pharmaceutical composition are formulated for at least two administrations, one in the morning and one in the evening, wherein the dosage schedule provides a relatively higher dose of beta blocker in the morning (the AM) than in the evening, and a relatively higher dose of an anti-inflammatory medication in the evening than in the morning.

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Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation: potential implications for cyclooxygenase-2 inhibition.

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The therapeutic combination of claim 116, wherein: (a) one, two or three or more drugs of the therapeutic combination are formulated as separate compositions; (b) one, two or three or more drugs of the therapeutic combination are formulated into one composition or drug formulation; or (c) one, two or three or more drugs of the therapeutic combination are formulated together.

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