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Although we could not address this overlap by recalculating all of the estimates reported in the reviews because of the effort involved, we do not expect that such adjustments would alter our conclusions.
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The last variable in Equation 1 is the interindividual differences among patients, which can shift the dose-response curve making patients either more or less sensitive to the effect of the drug.
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McRobbie H, Hajek P: Effects of rapid smoking on post-cessation urges to smoke.
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For this reason, such “masked” DDIs can ironically lead to the use of more medications to treat the apparent worsening of the primary condition or to treat the apparent emergence of a new condition.
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Conversely, reduced hippocampal excitability accompanies anxiogenic effects observed in 24 h WD animals ( and ) and following treatment with varenicline during 24 h WD ().
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As expected, 7-day point-prevalence abstinence rates were higher for the varenicline group than the placebo group at week 12 (46.
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The subject invention provides a varenicline composition that comprises varenicline, or a pharmaceutically acceptable salt thereof, and an amount of a compound selected from one or more of several mononitro, monoamino, mixed aminonitro, diamino or dinitro intermediates, and the concentration of said.
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Effective behavioral interventions include in-person behavioral support and counseling, telephone counseling, and self-help materials ().
Smoking-cessation outcomes had to be reported at 6 months or later to be included; findings on smoking reduction (based on frequency or quantity only), intention to quit, and cessation at less than 6 months were excluded.
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This work was supported by the National Institutes of Health National Cancer Institute (P50-CA143187) and the National Institutes of Health National Institute on Drug Abuse (1-F32-DA026236, 1-K99-DA032681, DA024787-01A1S1).
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